“Label-free Optical Micro Imaging and Tissue Histology in vivo”

This seminar will present our recent development of high-resolution biophotonic imaging technologies, including optical coherence tomography (OCT) and multiphoton endomicroscopy. These technologies have shown significant translational potential for imaging tissue microanatomies in vivo at a resolution approaching or at standard histopathology but without the need for tissue removal, staining or processing. The physics principles, engineering challenges and solutions will be briefly discussed, including the development of advanced lasers, MEMS technology, custom optical fiber, and ultracompact, high-performance imaging optics. Representative applications of these high-resolution technologies will be presented, including cancer detection, airway physiology assessment, preterm birth risk assessment, and intra-operative guidance for neurosurgery. Other potential applications towards basic research such as functional neuroimaging on awake animals will also be discussed.

Short Biography: Dr. Xingde Li received his PhD degree in Physics and Astronomy from the University of Pennsylvania in 1998. He is currently a professor at the Department of Biomedical Engineering, Johns Hopkins University. Prior to joining Hopkins, he was with the Department of Bioengineering, University of Washington in Seattle for about 8 years. He has received several awards including The Teacher of the Year Award (BioE at UW), the NSF Faculty Early Career Award, the International Association of Dental Research Innovation in Oral Care Award, and the Hartwell Foundation Individual Biomedical Research Award. He has published about 85 peer-reviewed journal papers, with total citations >9,000 and an H-index~39 (according to Google Scholar). He has delivered more than 100 invited talks (including some plenary talks) at conferences and outside research institutions. He has been chairing many conferences such as the recent OSA Biomedical Optics Topical Meetings 2010-2014 etc. He currently serves on the editorial board of several international journals including the Journal of Biomedical Optics (SPIE), Biomedical Optics Express (OSA), the IEEE Transactions on Biomedical Engineering, Light: Science and Applications (Nature Publishing Group and CIOMP) etc. He is a Fellow of OSA, SPIE, and AIMBE. His personal website is http://www.bme.jhu.edu/people/primary.php?id=915. The seminar will be followed by a reception of light hors d’oeuvres and wine.

When: Thursday May 29, 2014 4:10 PM

Where: 1005 GBSF