Deirdre R. Meldrum Arizona State University Senior Scientist Professor of Electrical Engineering Director of the Biosignature Initiative Director of the Center for Biosignatures Discovery Automation in the Biodesign Institute PI/Director of the NIH Center of Excellence in Genomic Sciences: Microscale Life Sciences Center

“Biosignatures Automation for Improved Human Health”

Everyone has the goal of living a long, healthy life. Our society aspires to chronic health. Biosignatures would enable a health care system that focuses on keeping healthy people healthy and reducing the time sick people spend in hospitals and in clinical care. The goal is to enable the prediction of disease risk and the prevention of disease, with pre-symptomatic diagnosis and interventional therapeutic treatment of individuals based upon their personal biosignature – all the information about an individual (genomic, proteomic, cellomic, imaging, behavior, and other information) that enables prediction of disease predisposition and future health status. This presentation will address the key challenges required to discover and implement biosignatures in a nation-wide health care program. Specifics will be provided on single cell biosignatures including the quantification of physiological and morphological manifestation of underlying gene and protein alterations with disease. Examples will be provided with lung cancer, esophageal cancer, and breast cancer. Successful implementation of biosignatures in a nation-wide health care program will require high-throughput automation for biosignature discovery, clinical validation, standardization, and qualification for use in pre-symptomatic diagnoses, drug development research, commercialization, and patient management for healthy patient outcomes.

Thursday, May 3, 2012 4-5 p.m.
Kemper Hall 1065