Applications of Single Compartment Models to Pharmacokinetics
Basic biophysical mass balance analysis is critical in the study of drug absorption, distribution, metabolism, and excretion in the body. Drug concentration over time can be plotted in pharmacokinetic profiles, in which the effects of dose, route, and schedule of administration can be determined. An overview of basic mass balance analysis will be presented, and several single compartment models that can be used to model various pharmacokinetic profiles will be discussed. These include single compartment models for various modes of drug administration, involving absorption, bolus injection, or constant infusion. Lastly, the relevance of pharmacokinetics in the development of new drug / device products will be discussed.
Short Biography: Jennifer Choi is currently teaching in the Biomedical Engineering Department at Rutgers University. Prior to joining Rutgers, she was a postdoctoral fellow at Advanced Technologies and Regenerative Medicine, a former Johnson and Johnson Company, where she conducted mechanism of action, feasibility, and efficacy studies for key therapeutic areas. She received her doctoral degree in Biomedical Engineering from Tufts University, in which her research focused on adipose tissue engineering for soft tissue regeneration. She received her M.S. degree from Syracuse University, and B.S. degree from Cornell University.