4:10 pm to 5:00 pm
“Particles, photons, and phages”
Combustion-generated, and intentionally generated nano materials can pose significant threats to human health. The engineering of novel materials can provide new tools for application to nano toxicology. In particular, the use of lanthanide-based phosphor materials can provide new ways of examining the toxicity and translocation of these materials in living systems. In addition to their potential toxicity, nano materials offer many new and exciting possibilities for application to sensing the environment around us and within our bodies. Super-paramagnetic nanoparticles have been used in a rotating microfluidic system with a stationary magnetic field to assemble long chains that improved mixing under very low Reynolds number conditions. The interaction of magnetic forces between particles and fluid forces that break them up have been examined and exploited to produce enhanced assays for proteins and other biomolecules. The optical properties of up-converting phosphors have been used to produce a new class of optically-active nano materials for use in a wide range of biological applications that will be discussed. Finally, the electrophoretic manipulation of nano particles, including bacteriophages that infect bacteria, into the structure of a photonic crystal has been demonstrated to provide an incredibly sensitive platform for application of both protein and DNA assays for use in a wide variety of possible biological applications: in the detection of infectious diseases; detection of protein biomarkers of disease; in the detection of mutations in DNA; finally, in the detection of bacteriophages that may have a significant economic impact on fermentation processes, including the dairy industry and the pharmaceutical industry.